Exercise may lead to faster prostate tumor growth
Prostate tumors grew more quickly in mice who exercised than in those who did not, leading to speculation that exercise may increase blood flow to tumors, according to a new study by researchers in the Duke Comprehensive Cancer Center (DCCC) and the Duke Prostate Center. Our study showed that exercise led to significantly greater tumor growth than a more sedentary lifestyle did, in this mouse model," said Lee Jones, Ph.D., DCCC and senior investigator on this study.
Our thought is that we may, in the future, be able to use this finding to design better drug delivery models to more effectively treat prostate cancer patients, and those with other types of cancer as well." The findings were presented in a poster session at the American Association for Cancer Research annual meeting on April 13 in San Diego, Calif.
The study was funded by the United States Department of Defense, the Prostate Cancer Foundation and the American Urological Association Foundation, Rising Star in Urology Award, given to Stephen Freedland, one of the study"s investigators. The researchers implanted prostate tumors subcutaneously in the flanks of 50 mice and then put half of the mice in cages with exercise wheels and half in cages with no wheels. All mice were fed the same diet. On average, the exercising mice ran more than half a mile each day.
Researchers and clinicians know that a challenge in delivering chemotherapy and radiation to tumors can be their poor blood flow, so these findings may hint at a way in which to improve blood flow to tumors, perhaps then allowing for better distribution of medicine, he said.
We"re wondering, can we combine exercise with treatments such as chemotherapy, hormone therapy or radiation, to maximize the results we achieve in prostate cancer patients," Jones said. That question will be the subject of subsequent studies."
The researchers are currently conducting a validation study, in mice, in which tumors are injected directly into the prostate, thereby better simulating human prostate cancer, Jones said. Down the line, we will test this hypothesis in humans undergoing medical treatment for prostate cancer," he said.
The researchers want to caution men against interpreting these findings as an endorsement for not exercising for fear of getting or exacerbating cancer. These mice were not receiving treatment and we were allowing aggressive tumors to grow unchecked for the sake of the experiment," said study investigator Freedland, a urologist at Duke.
Patients would not find themselves in the same situation." This study gives us insight into which cellular pathways are affected by exercise, and starts to give us clues about how to harness the beneficial effects," said Michael Potter, a medical student at Duke and lead investigator on the study.
Ultimately, we hope that this knowledge will help us use exercise to both deliver medicines more effectively and protect the body from the harmful side effects of treatment, as we already know it can."
This is one of the first studies to look at the physiological effects of exercise on the tumor itself, rather than examining the quality-of-life or symptom-control effects of exercise in cancer patients, Jones said. The findings were a bit surprising, but provide a very important and exciting foundation upon which to build," he said. Other researchers involved in this study include Susan Poulton and Mark Dewhirst.
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Wausau Daily Herald - Town Chatter: Expectant mom directs shower gifts to friends
Matson asked her guests -- instead of bringing gifts -- to donate $5 to a fund for Keyshon Ivey, the 1-year-old son of Holly Mecikalski and her boyfriend, Randal Ivey. Keyson has short-gut syndrome and faces many medical procedures and possibly a transplant. The shower raised $250; $150 was given to Mecikalski to help with medical bills and $100 will be used to start another fundraiser that Matson is planning for Keyshon in the near future.
Matson said she also received plenty of gifts from her generous guests. Gerald Morris, Wausau, author of the popular "Squire's Tales" series, will have a new series of books out this May. The Adventures of Sir Lancelot the Great" is the first book in "The Knights Tales" series for middle-grade readers. Morris depicts the tales of Sir Lancelot in a humorous manner to attract young readers to the traditional tale.
The 96-page book is writen for grades one through five and sells for $16. While the rest of us were trying to find ways to relax during spring break, Chelsea Lorge and James Brodzeller joined in on a 200-mile walk across Wisconsin. Both are D.C. Everest Senior High School graduates and University of Wisconsin-Stevens Point students.
Lorge and Brodzeller were among 11 walkers from UWSP and the school's Environmental Council participating in the annual Eagle Walk to support the Wisconsin chapter of the Nature Conservancy. Around $2,000 was raised by the five walkers who completed the trek and the six who walked part of it, according to Katie Adams, one of the Eagle Walk organizers. This was Brodzeller's first year participating in the walk.
He said he made the mistake of wearing hiking boots instead of walking shoes and really could feel it in his shins during and after the walk. The Nature Conservancy in Wisconsin has protected more than 139,000 acres of forests, wetlands, prairies, lakes and streams since 1960. Gannett Company website. Use of this site signifies your agreement to the Terms of Service and Privacy Policy, updated April 11, 2007.
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House Panel Addresses the Would-Be Student Loan Crisis :: Inside Higher Ed :: Higher Education's Source for News, and Views and Jobs
Permit the Department of Education to serve as a "secondary market of last resort" that would buy loans from lenders in the Federal Family Education Loan, or guaranteed loan, program that have been otherwise unable to raise new funds. We have taken critical steps today toward ensuring that the credit crisis in the financial markets does not jeopardize our federal student loan programs," said Rep.
Rubn Hinojosa (D-Tex.) House Subcommittee on Higher Education, Lifelong Learning, and Competitiveness, who co-sponsored the bipartisan bill.
Not surprisingly, the passage of the bill earned applause from lenders and predictions that the legislation would "represent a significant boon to the for-profit post-secondary companies," as Trace Urdan, an analyst with Signal Hill, put it in an e-mail message Wednesday. But it also came in for some criticism from advocates for students. The U.S.
Public Interest Research Group and the United States Student Association sent a letter to members of Congress in which they generally praised the expanded flexibility for parent loans but expressed a mixed assessment of the expanded loan limits.
Extending credit to students, while doing nothing to ensure that the most predatory schools are restricted from siphoning it off, offers little help to the low-income students typically preyed upon by such schools. Any increase in loan limits without significant enhancements to. Doug Lederman Want it on paper? Know someone who’d be interested? Forward this story. Want to stay informed?
Advertisement Comments Truth is stranger than fiction The Minority Report (the movie) has correctly captured the new zeitgeist of higher education. While no student or college has reported any problems accessing federal student aid to date" (emphasis added)." No one has been hurt, but they "might" be. I think I have heard this refrain before.
Thank you Mr. Cuomo. We now have a new standard for action. An asteroid could fall on our heads. I think we need a program to destroy all asteroids before this happens. If I lose my job I could become poor, I think the taxpayers should give me ten million dollars to make sure this does not happen.
It has not happened, but it might.. Chimera, at 8:45 am EDT on April 10, 2008 House hearings on federal student loans Very informative article.. If what we’ve read is true, this could indeed impact funding prospects for the security auctions needed over the next quarter to fund student loans for the September crunch when school starts again.
I do hope these hearings will at least expose what deregulation hath wrought in this new global economy. We have a lot of MBA cowboys out there dreaming up crazy quilt, get-rich-quick lending schemes that end up blowing up into Bear Stearns spectacles. These schemes mutate into the public domain as teaser-rate mortgages given to folks with no income verification required.
Then, two years later, when folks can’t keep up with these ARM mortgages, they default. You should not have to graduate Wharton to understand how your mortgage works. Kudos to the Congress for these hearings. Let’s hope they wake people up. 9:05 am EDT on April 10, 2008 try getting a private education loan..
The credit crunch is very real and although Congress is trying to make sure the incompetent Spellings-led ED ensures FFELP and DL for students; and student who depends of private loans to supplement their education is in dire trouble.
However you feel about Cuomo’s effort to police the national tertiary education system from NY’s AG office is irrelevant to this situation. Derek, at 11:30 am EDT on April 10, 2008 Irrelevant?? Not a problem as I have a great credit score. It is those who do not who will have a problem. The credit crunch is very real and although Congress is trying to make sure the incompetent Spellings-led ED ensures FFELP and DL for students; and student who depends of private loans to supplement their education is in dire trouble."
I never said anything about the credit crunch, your conclusion is based on air. It is indeed real. We agree about the incompetence of Spellings et al. As far as students needing to supplement their education, it is the "supplementing" that is a part of the problem. If a poor student cannot get a private loan there are other alternatives, including transferring to a less expensive school. Again, not worried about rich students who are by far the major borowers of these loans.
However you feel about Cuomo"s effort to police the national tertiary education system from NY"s AG office is irrelevant to this situation." My comparisons had more to do witn my observation of the "new standard" i.e. Politicians with a solution looking for a problem frighten me, and they should frighten you too. My "feelings" about Cuomo are probably too complicated for you to understand, but are not the issue.
I may be a fool, but I know when I am be played for a fool. Get past you self serving attitude. Chimera, at 3:15 pm EDT on April 10, 2008 You Can Bet Your Sweet Bippy.. Not hot air. I just received my FAFSA statement saying that I was not eligible for aid - not even a loan.
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Feldman Mall Properties, Inc. Announces Continued Delay in Filing Form 10-K
April 9 PRNewswire-FirstCall -- Feldman Mall Properties, Inc. Annual Report on Form 10-K for the year ended December 31, 2007. The additional time is required in order to complete its normally required year-end reporting requirements and assessment of the effectiveness of its internal controls over financial reporting, as required by Section 404 of the Sarbanes-Oxley Act of 2002.
The Company intends to file its Annual Report on Form 10-K for the year ended December 31, 2007 as soon as possible. About Feldman Mall Properties Feldman Mall Properties, Inc. Feldman Mall Properties Inc.' Class A malls through comprehensive renovation and re-tenanting efforts aimed at increasing shopper traffic and tenant sales.
For more information on Feldman Mall Properties Inc., Company's website at http: www.feldmanmall.com.
Forward-looking Information This press release contains forward-looking statements that involve risks and uncertainties regarding various matters, including, without limitation, the success of our business strategy, including our acquisition, renovation and repositioning plans; our ability to close pending acquisitions and the timing of those acquisitions; our ability to obtain required financing; our understanding of our competition; market trends; our ability to implement our repositioning plans on time and within our budgets; projected capital and renovation expenditures; demand for shop space and the success of our lease-up plans; availability and creditworthiness of current and prospective tenants; and lease rates and terms.
The forward-looking statements are based on our assumptions and current expectations of future performance. These assumptions and expectations may be inaccurate or may change as a result of many possible events or factors, not all of which are known to us. If there is any inaccuracy or change, actual results may vary materially from our forward-looking statements. A Time Warner Company. All Rights Reserved.
Terms under which this service is provided to you. Market indexes are shown in real time, except for the DJIA, which is delayed by two minutes. All times are ET. Time reflects local markets trading time. 8224; - Intraday data delayed 15 minutes for Nasdaq, and 20 minutes for other exchanges. Disclaimer Copyright © 2008 BigCharts.com Inc. All rights reserved. Please see our Terms of Use.
MarketWatch, the MarketWatch logo, and BigCharts are registered trademarks of MarketWatch, Inc. Intraday data delayed 15 minutes for Nasdaq, and 20 minutes for other exchanges. All Times are ET. Historical, current end-of-day data, and splits data provided by FT Interactive Data. Fundamental data provided by Hemscott. SEC Filings data provided by Edgar Online Inc..
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Moultrie Observer - Quality Employment wins Pony opener
Matt Creech was the winning pitcher and also added two hits. Vann Pitts had two hits and Dykes had another hit in addition to his home run. The victory raises Quality Employment's record to 3-0. Southwest Georgia Bank falls to 1-2. In Monday's other Pony League game, VFW crushed Edwards Motors 13-3. Aubrey McCarty was the winning pitcher and Jimmy Skeen and Drew Marchant each had two hits for VFW, now 1-2.
Edwards Motors falls to 0-3. Clayton Brown went the distance on the mound and was 3-for-3 with a home run to lead the Quality Employment Midget League team to a 9-6 victory over Southwest Georgia Insurance on Monday. Kyle Ashley also had two hits for Quality Employment, now 2-1. Southwest Georgia Insurance falls to 1-2.
In Monday's other Midget League game, Davis Insurance defeated Southwest Georgia Bank 4-1. O'Shay Williams was the winning pitcher. Cole Bryant also threw for the Davis Insurance. Williams, Bryant and Wade Hawes each had two hits for Davis Insurance, now 1-2. Andy Bush had three hits and Eric Gould had two for Southwest Georgia Bank, now 0-2.
In last Friday's games, Ameris defeated Southwest Georgia Insurance 8-4 and Mobley Plant won over Davis Insurance 7-1. Rocky's pounded Wendy's 11-1 in one of the two Farm League games on Monday. All Rights Reserved. 25 N. Main St.,
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Education review to ease skills shortage - Breaking News - National - Breaking News
Welcome to The Sydney Morning Herald. Skip directly to: Search Box, Section Navigation, Content. Text Version. Addressing the Higher Education HR conference in Sydney on Thursday, Mr O'Connor said the review announced last month by Education Minister Julia Gillard would reverse the skills shortage. It would look at creating high performance institutions and improving the sector's contribution to increased economic productivity and labour market participation, he said.
Increasing productivity will be critical for Australia in the coming years, particularly under the cloud of the current skills shortage," Mr O'Connor said. A lack of investment by the former Liberal government in education and training has left our nation with the biggest shortages in labour ever experienced."
The review would also look at improving university funding arrangements, allow wider access to higher education for students from all backgrounds and ensure high education standards, he said. Our government knows the education system is important not only for its contribution to the economy but also in building critical thinking and giving us a better understanding of our place in the world," Mr O'Connor said. The Sydney Morning Herald.
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The Associated Press: L.A. Music School Named for Herb Alpert
The grant will pay for three faculty chairs, student scholarships and music programs & x2014; including a student-run record label & x2014; at the newly minted Herb Alpert School of Music at CalArts, school president Steven D. Lavine said.
Albert and his wife, vocalist Lani Hall, pledged the money through his Herb Alpert Foundation, which has already donated some $9 million to the school. The musician said CalArts impressed him from his first visit to the campus. Here was this place to take great leaps, to prepare artists to reach beyond what they know," he said. Alpert became an overnight star when the Tijuana Brass released the trumpet-drive instrumental "The Lonely Bull" in the early 1960s.
He and business partner Jerry Moss later formed A&M Records. Albert donated $30 million to fund a new music school at the University of California, Los Angeles last year. Hosted by Copyright © 2008 The Associated Press.
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Halifax Travel Insurance: 'Bubble Brits' stay poolside - Money News
It found that rather than attempting to experience the local culture, many Britons prefer an all-inclusive package holiday, while three-quarters make no attempt to speak the language. Around 4.3 million people in the UK take a package holiday to an exotic destination every year, 800,000 of whom choose an all-inclusive deal whereby drinks and food are provided by their hotel. Paul Birkhead, senior underwriting manager at Halifax Travel Insurance, said that even those planning to stay by the pool will still need travel insurance.
He warned: "Holidaymakers should not be lulled into a false sense of security thinking they are immune from things going wrong just because they won't be going anywhere other than the hotel." For those who choose to make their trip abroad more permanent, Halifax recently launched two new international savings accounts aimed at expatriates.
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San Luis Obispo County"s website 04 09 2008 Local Calendar for April 9
Hike along Montaña de Oro's Bluff Trail for views and possible sightings of a variety of birds, plants and sea life. Meet at the trailhead, 200 yards south of Visitor Center at Montaña de Oro State Park. 2.5 miles, 2 hours. Rain or bad weather cancels outdoor activities. 772-2694 or www.morrobaymuseum.org. MORE TODAY Book Finders Discussion Group. 10:30 a. The Diving Bell and The Butterfly" by Jean-Dominique Bauby.
San Luis Obispo City County Library, 995 Palm St., San Luis Obispo. Spencer's on the corner of Courtland and East Grand. 544-9570. Sunken Gardens at El Camino Real and The East Mall.239-6535. THURSDAY Adventures With Nature. 8226; Sand Spit Walk. 9 a. Examine dune plants while watching the surf and looking at whatever has washed in.
Watch birds feed and consider their adaptations for contact with a cold salty environment. Meet at Montaña de Oro State Park in the Sand Spit Parking Lot. Turn right on paved road 0.8 miles from park entrance. 9 miles, 4.5 hours. Astrology Readings. 11 a. 4 p. Thursday and April 17. Harry Farmer gives individual astrology readings. Coalesce Bookstore, 845 Main St., Morro Bay.
Donations. 772-2880. Best of Hollywood." 7 p. Thursday and Friday; 2 and 7:30 p. Saturday. Presented by Nipomo High School, Mesa Middle School and Paulding Middle School. Saturday evening preshow gala includes light dinner, beverages, mingling with cast members and show. Clark Center, 487 Fair Oaks Ave., Arroyo Grande. Portuguese Fado singer. Doors open at 7:30 p.
Congregation Beth David, 10180 Los Osos Valley Road, San Luis Obispo. Tickets, 541-0657; information, 783-2346.
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Broadway musical about weddings as minefields - Arts - NJ.com
A Catered Affair. Where: Walter Kerr Theatre, 219 W. 48th St., New York. When: Now in previews, opens April 17. Mondays-Saturdays at 8 p.m.; Wednesdays and Saturdays at 2 p.m. How much: $29.50-119.50. The film "Father of the Bride" depicted a wedding as a bittersweet rite of passage.
The Wedding Singer" likened receptions to no-holds-barred confessionals. The Graduate" concluded with wedding interruptus. Now there's "A Catered Affair," a new Broadway musical about weddings as minefields, gingerly negotiated by mothers and daughters.
Based on the 1956 M-G-M film "The Catered Affair" (starring Bette Davis and Debbie Reynolds), the musical is written by Harvey Fierstein and John Bucchino and stars longtime Broadway star Faith Prince with Livingston native Leslie Kritzer. The show explores the relationship between Aggie, a woman who feels life has passed her by, and her daughter, Janey, who is about to be married to Ralph.
Money is tight, but Aggie wants to give Janey a big wedding -- a "catered affair." Sitting in the back of the Walter Kerr Theatre, where the show is in previews before opening April 17, Kritzer chatted with The Star-Ledger.
She is perhaps best known to New Jersey audiences for her acclaimed performance in the 2001 production of "Funny Girl" at the Paper Mill Playhouse in Millburn. Prince arrived shortly afterward, carrying a container of matzo ball soup for lunch. Leslie, when did you first meet Faith?
Leslie Kritzer: I first met Faith Prince when she came to speak at my school, the University of Cincinnati College-Conservatory of Music, which is her alma mater as well. Reporters went backstage and talked with Faith, and I thought, "I want to be like her." I never got to see her in the show, but I bought a CD and listened to it over and over. I was fixated on Faith Prince. So when she came to visit the conservatory, she signed my CD.
The next time I saw her was at a reading of "A Catered Affair" in July 2007, years later. What was that moment like for you? LK: It was really awesome. It's been a surreal experience, to work with someone whom I grew up idolizing. Just, wow! I can't believe I'm playing your daughter. She's been so warm and lovely to me. Like a mom to me and a friend. Mother-daughter relationships are complicated.
LK: Moms know how to push your buttons. When I'm around my mother in real life, I have a tendency to be on the defensive. This role allows me to really show that. Also, frequently you want to please your mother but still be who you are.
You want to be a woman in your own right but you want your mother to be happy. Aggie never had the wedding she wanted, but Janey can give Aggie that wedding through her own. I do that in real life; I try to give my mom hope and inspiration. You and Faith share a lovely song: "One White Dress." Is that a turning point?
LK: Aggie has never taken her daughter shopping, and Janey has never tried on something as beautiful as that dress or heard her mother say "You're beautiful." It's the first time Janey buys into the idea that a big wedding might be a good thing. She's a very practical girl. She doesn't think about pretty and not pretty.
In that very private moment, she thinks about herself as beautiful for the first time and she also hears the story about how her mother and father got married. She starts to want the wedding for her mom as well as for herself. Faith Prince: Leslie's my favorite person I've ever been on stage with. LK: Oh, my God. Hearing that makes me tear up. FP: I'm telling you. I mean, like, ever. Because we are just there to serve the piece and not ourselves. There's something incredibly freeing about that.
That feeling is why I got into this business. And you rarely have it, because most of the time -- I hate to say it -- a lot of actors are in it for themselves. But this has been a joyous experience. So she can never get another job. What motivates Aggie? FP: Aggie has immense love, but doesn't know how to express it. She's stopped her feelings.
Her marriage got off on the wrong track, and she doesn't think her husband loves her.. Â. Â. She's one of those mothers who withholds. Her son has died. Janey wants to leave home. It all throws a wrench. But Aggie finally decides, let's move on to something we can put our energy into, which would be a wedding. What is the fixation with big weddings? What kind of a wedding did you have, Faith?
FP: I eloped. LK: I'm not married. FP: The last thing I wanted was to plan something for 100,000 people and walk down the aisle in a white dress. For a lot of people it's their glory moment. Everybody's come to witness this thing. But there's so much agenda. That's why I didn't do it. Did either of you watch the M-G-M film? LK: Once. I watched it to get the feel, the tone.
Then I left it alone, because I'm just way too good a mimic. FP: She's an amazing mimic. I have a hard time imagining Debbie Reynolds in the Bronx. FP: But you know how I took it? As a woman of that time trying to get out of the Bronx. Dyeing her hair blond, trying to be not like her parents. LK: My mom grew up in the Bronx during the early 1950s, one of seven brothers and sisters.
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